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Spermatogonial Cell-Mediated Activation of an IκBζ-Independent Nuclear Factor-κB Pathway in Sertoli Cells Induces Transcription of the Lipocalin-2 Gene

2 Dec 2005

Abstract excerpt

In spermatogenesis, Sertoli cells serve as supporting cells for the proliferation and differentiation of germ cells. However, it appears that Sertoli cell function is regulated by adjacent spermatogonial cells in the testis because expression of lipocalin-2 mRNA, which encodes an iron-siderophore-binding protein, is barely detectable in Sertoli cells of germ cell-deficient W/Wv mice, and more abundantly expressed...

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PMID: 16322095
DOI: 10.1210/me.2005-0423

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