Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel role for a sterol response element binding protein in directing spermatogenic cell-specific gene expression.

Molecular and cellular biology - 1 Dec 2004

Wang Hang, San Agustin Jovenal T, Witman George B, Kilpatrick Daniel L

Abstract excerpt

Sperm are highly specialized cells, and their formation requires the synthesis of a large number of unique mRNAs. However, little is known about the transcriptional mechanisms that direct male germ cell differentiation. Sterol response element binding protein 2gc (SREBP2gc) is a spermatogenic cell-enriched isoform of the ubiquitous transcription factor SREBP2, which in somatic cells is required for homeostatic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3T3-L1 Cells
Share to 5' Flanking Region

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enzyme Precursors

Share to Helix-Loop-Helix Motifs

Share to Leucine Zippers

Share to Spermatids

Share to Sterol Regulatory Element Binding Protein 2

Share to Sterols

Source

Open in PubMed Open full text

Identifiers

PMID: 15572673
DOI: 10.1128/MCB.24.24.10681-10688.2004
PMCID: PMC533981

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel role for a sterol response element binding protein in directing spermatogenic cell-specific gene expression.PMID 15572673Read ↗

Identification and Integrative Analysis of 28 Novel Genes Specifically Expressed and Developmentally Regulated in Murine Spermatogenic CellsSemantic proximity Read ↗

MicroRNA-202 maintains spermatogonial stem cells by inhibiting cell cycle regulators and RNA binding proteinsSemantic proximity Read ↗

Genome-wide identification of AR-regulated genes translated in Sertoli cells in vivo using the RiboTag approach.Semantic proximity Read ↗

MicroRNA signature in various cell types of mouse spermatogenesis: Evidence for stage‐specifically expressed miRNA‐221, ‐203 and ‐34b‐5p mediated spermatogenesis regulationSemantic proximity Read ↗

MicroRNA-184 downregulates nuclear receptor corepressor 2 in mouse spermatogenesisSemantic proximity Read ↗

Stage-specific gene expression is a fundamental characteristic of rat spermatogenic cells and Sertoli cellsSemantic proximity Read ↗

Testis-specific transcription mechanisms promoting male germ-cell differentiationSemantic proximity Read ↗

Expression of germ cell nuclear factor (GCNF/RTR) during spermatogenesisSemantic proximity Read ↗

Expression of the Putative Sterol Binding Protein Stard6 Gene Is Male Germ Cell Specific1Semantic proximity Read ↗

Germline FOXJ2 overexpression causes male infertility via aberrant autophagy activation by LAMP2A upregulationSemantic proximity Read ↗

Alteration of protein prenylation promotes spermatogonial differentiation and exhausts spermatogonial stem cells in newborn mice.Semantic proximity Read ↗

Identification of Differentially Expressed Genes in Mouse SpermatogenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.