Article
Molecular and functional characterization of the murine ldh2 promoter region: Sp-binding GC-box domains are the key cis-elements regulating ldh2 gene expression during spermatogenesis.
Molecular and cellular endocrinology - 25 Nov 2008
Chen Xing, Yang Jun, Sung Dae-Yong, Thompson Winston, Walker William, Thomas Kelwyn
Abstract excerpt
The goal of the present study was to elucidate the specific transcriptional mechanisms that regulate ldh2 gene expression during the early stages of spermatogenesis. DNA sequence analysis of the 1.0-kb ldh2 promoter region directly upstream of the transcriptional start site indicated the presence of three SP-protein binding GC-box elements and the absence of TATA and CAAT boxes. Functional characterization...
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