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Article

Germline FOXJ2 overexpression causes male infertility via aberrant autophagy activation by LAMP2A upregulation

30 Jul 2022

Abstract excerpt

Abstract Spermatogenesis is a complex biological process that produces haploid spermatozoa and requires precise regulation by many tissue-specific factors. In this study, we explored the role and mechanism of Fork head box J2 (FOXJ2, which is highly expressed in spermatocytes) in the regulation of spermatogenesis using a germline-specific conditional Foxj2 knock-in mouse model (Stra8-Cre; Foxj2tg/tg mouse). Foxj2...

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PMID: 35908066
DOI: 10.1038/s41419-022-05116-w

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