Article
Glucose tolerance female-specific QTL mapped in collaborative cross mice.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Feb 2017
Abu-Toamih Atamni Hanifa J, Ziner Yaron, Mott Richard, Wolf Lior, Iraqi Fuad A
Abstract excerpt
Type-2 diabetes (T2D) is a complex metabolic disease characterized by impaired glucose tolerance. Despite environmental high risk factors, host genetic background is a strong component of T2D development. Herein, novel highly genetically diverse strains of collaborative cross (CC) lines from mice were assessed to map quantitative trait loci (QTL) associated with variations of glucose-tolerance response. In total,...
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