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Article

Serotonin transporter and GABAA alpha 6 receptor variants are associated with neuroticism.

Biological psychiatry - 1 Feb 2004

Sen Srijan, Villafuerte Sandra, Nesse Randolph, Stoltenberg Scott F, Hopcian Jeffrey, Gleiberman Lillian, Weder Alan, Burmeister Margit

Abstract excerpt

BACKGROUND: A tendency to experience negative affect, as measured by the neuroticism component of the Neuroticism, Extraversion, and Openness Personality Inventory (NEO-PI), is a trait marker for major depression. Epidemiologic studies indicate a strong genetic component, but to date few specific genetic variants have been definitively implicated. A serotonin transporter promoter polymorphism (5-HTTLPR) has been...

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Identifiers

PMID: 14744464
DOI: 10.1016/j.biopsych.2003.08.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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