Article
Gender-specific association between serotonin transporter polymorphisms (5-HTTLPR and rs25531) and neuroticism, anxiety and depression in well-defined healthy Han Chinese.
Journal of affective disorders - 1 Jan 2017
Chang Chuan-Chia, Chang Hsin-An, Fang Wen-Hui, Chang Tieh-Ching, Huang San-Yuan
Abstract excerpt
BACKGROUND: A tri-allelic serotonin transporter promoter polymorphism (5-HTTLPR/rs25531) more effectively determines the levels of transcriptional efficacy than that with the bi-allelic 5-HTTLPR polymorphism in vitro. Both are reportedly associated with personality traits of negative emotionality, but with conflicting findings. One explanation for this is that a gender difference may play a role in genetic...
Topics
- Adult
- Alleles
- Anxiety
- Anxiety Disorders
- Asian People
- China
- Depression
- Female
- Genotype
- Humans
- Male
- Middle Aged
- Neuroticism