Neuroticism is not associated with the serotonin transporter (5-HTTLPR) polymorphism.

doi:10.1038/sj.mp.4000466

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Article

Neuroticism is not associated with the serotonin transporter (5-HTTLPR) polymorphism.

Molecular psychiatry - 1 Jan 1999

Flory J D, Manuck S B, Ferrell R E, Dent K M, Peters D G, Muldoon M F

Abstract excerpt

A deletion/insertion polymorphism in the transcriptional control region of the serotonin transporter gene (5-HTTLPR) was reported to be associated with dimensional measures of neuroticism, although subsequent replication attempts have failed. These replication attempts, however, have been dissimilar to the initial study in sample size, distribution of allelic frequency and/or assessment of neuroticism. The...

Topics

Adult
Analysis of Variance
Black People
Carrier Proteins
Cholesterol
Female
Genotype
Homozygote
Humans
Male
Membrane Glycoproteins
Membrane Transport Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nerve Tissue Proteins

Neurotic Disorders

Pennsylvania

Polymorphism, Genetic

Promoter Regions, Genetic

Reference Values

Source

Open in PubMed

Identifiers

PMID: 10089017
DOI: 10.1038/sj.mp.4000466

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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