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Article

The serotonin transporter length polymorphism, neuroticism, and depression: a comprehensive assessment of association.

Biological psychiatry - 15 Sept 2005

Willis-Owen Saffron A G, Turri Maria G, Munafò Marcus R, Surtees Paul G, Wainwright Nick W J, Brixey Richard D, Flint Jonathan

Abstract excerpt

BACKGROUND: A promoter-based length polymorphism (5-HTTLPR) of the human serotonin gene (SLC6A4) has exhibited inconsistent association with emotionality phenotypes, such as major depression (MD) and the personality trait neuroticism (N). Several explanations have been posited to account for this discrepancy, including underpowered experimental design and variation in gender ratio, age, and ethnicity. METHODS:...

Topics

Depression
Female
Genotype
Humans
Male
Neurotoxicity Syndromes
Personality
Personality Inventory
Polymorphism, Genetic
Psychiatric Status Rating Scales
Serotonin Plasma Membrane Transport Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16023085
DOI: 10.1016/j.biopsych.2005.04.050

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-16023085-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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