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Article

Restricted Sequence Variation in Streptococcus pyogenes Penicillin Binding Proteins.

mSphere - 29 Apr 2020

Hayes Andrew, Lacey Jake A, Morris Jacqueline M, Davies Mark R, Tong Steven Y C

Abstract excerpt

A recent clinical report has linked Streptococcus pyogenes β-lactam antibiotic resistance to mutation in the penicillin binding protein (PBP) PBP2x. To determine whether this is an isolated case or reflects a broader prevalence of mutations that might confer reduced β-lactam susceptibility, we investigated the relative frequency of PBP sequence variation within a global database of 9,667 S. pyogenes isolates. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32350098
DOI: 10.1128/mSphere.00090-20
PMCID: PMC7193039

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