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Article

PBP active site flexibility as the key mechanism for beta-lactam resistance in pneumococci.

Journal of molecular biology - 10 Apr 2009

Contreras-Martel Carlos, Dahout-Gonzalez Cécile, Martins Alexandre Dos Santos, Kotnik Miha, Dessen Andréa

Abstract excerpt

Penicillin-binding proteins (PBPs), the main targets of beta-lactam antibiotics, are membrane-associated enzymes that catalyze the two last steps in the biosynthesis of peptidoglycan. In Streptococcus pneumoniae, a major human pathogen, the surge in resistance to such antibiotics is a direct consequence of the proliferation of mosaic PBP-encoding genes, which give rise to proteins containing tens of mutations....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19233207
DOI: 10.1016/j.jmb.2009.02.024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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