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Article

Effect of single amino acid substitution on oxidative modifications of the Parkinson's disease-related protein, DJ-1.

Molecular & cellular proteomics : MCP - 1 Feb 2012

Madian Ashraf G, Hindupur Jagadish, Hulleman John D, Diaz-Maldonado Naomi, Mishra Vartika R, Guigard Emmanuel, Kay Cyril M, Rochet Jean-Christophe, Regnier Fred E

Abstract excerpt

Mutations in the gene encoding DJ-1 have been identified in patients with familial Parkinson's disease (PD) and are thought to inactivate a neuroprotective function. Oxidation of the sulfhydryl group to a sulfinic acid on cysteine residue C106 of DJ-1 yields the "2O " form, a variant of the protein with enhanced neuroprotective function. We hypothesized that some familial mutations disrupt DJ-1 activity by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22104028
DOI: 10.1074/mcp.M111.010892
PMCID: PMC3277756

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Effect of single amino acid substitution on oxidative modifications of the Parkinson's disease-related protein, DJ-1.PMID 22104028Read ↗

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