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Article

Formation of a stabilized cysteine sulfinic acid is critical for the mitochondrial function of the parkinsonism protein DJ-1.

The Journal of biological chemistry - 6 Mar 2009

Blackinton Jeff, Lakshminarasimhan Mahadevan, Thomas Kelly J, Ahmad Rili, Greggio Elisa, Raza Ashraf S, Cookson Mark R, Wilson Mark A

Abstract excerpt

The formation of cysteine-sulfinic acid has recently become appreciated as a modification that links protein function to cellular oxidative status. Human DJ-1, a protein associated with inherited parkinsonism, readily forms cysteine-sulfinic acid at a conserved cysteine residue (Cys106 in human DJ-1). Mutation of Cys106 causes the protein to lose its normal protective function in cell culture and model organisms....

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Source

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Identifiers

PMID: 19124468
DOI: 10.1074/jbc.M806599200
PMCID: PMC2649108

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Formation of a stabilized cysteine sulfinic acid is critical for the mitochondrial function of the parkinsonism protein DJ-1.PMID 19124468Read ↗

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