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Article

Monomer DJ-1 and its N-terminal sequence are necessary for mitochondrial localization of DJ-1 mutants.

PloS one - 1 Jan 2013

Maita Chinatsu, Maita Hiroshi, Iguchi-Ariga Sanae M M, Ariga Hiroyoshi

Abstract excerpt

DJ-1 is a novel oncogene and also a causative gene for familial Parkinson's disease (park7). DJ-1 has multiple functions that include transcriptional regulation, anti-oxidative reaction and chaperone and mitochondrial regulation. Mitochondrial dysfunction is observed in DJ-1-knockout mice and fry, and mitochondrial DJ-1 is more protective against oxidative stress-induced cell death. Although translocation of DJ-1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23326576
DOI: 10.1371/journal.pone.0054087
PMCID: PMC3542337

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