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A Ran-binding protein facilitates nuclear import of human papillomavirus type 16

11 May 2021

Abstract excerpt

Human papillomaviruses (HPVs) utilize an atypical mode of nuclear import during cell entry. Residing in the Golgi apparatus until mitosis onset, a subviral complex composed of the minor capsid protein L2 and viral DNA (L2/vDNA) is imported into the nucleus after nuclear envelope breakdown by associating with mitotic chromatin. In this complex, L2 plays a crucial role in the interactions with cellular factors that...

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PMID: 33974675
DOI: 10.1371/journal.ppat.1009580

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