Article
-449 C>G polymorphism of NFKB1 gene, coding nuclear factor-kappa-B, is associated with the susceptibility to ulcerative colitis.
World journal of gastroenterology - 21 Dec 2012
Hayashi Ranji, Tahara Tomomitsu, Yamaaki Tsukasa, Saito Takashi, Matsunaga Kazuhiro, Hayashi Nobuhiko, Fukumura Atsushi, Ozaki Kazuaki, Nakamura Masakatsu, Shiroeda Hisakazu, Tsutsumi Mikihiro, Shibata Tomoyuki, Arisawa Tomiyasu
Abstract excerpt
AIM: To clarify the association between a polymorphism -449 C>G (rs72696119) in 5'-UTR of NFKB1 with ulcerative colitis (UC). METHODS: The studied population comprised 639 subjects, including patients with UC (UC cases, n = 174) and subjects without UC (controls, n = 465). We employed polymerase chain reaction-single strand conformation polymorphism to detect the gene polymorphism. RESULTS: The rs72696119 G...
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