Article
Study of polymorphisms in the interleukin-4 and IL-4 receptor genes in a population of Brazilian patients with multiple sclerosis.
Arquivos de neuro-psiquiatria - 1 Mar 2007
Quirico-Santos Thereza, Suppiah Vijayaprakash, Heggarty Shirley, Caetano Regina, Alves-Leon Soniza, Vandenbroeck Koen
Abstract excerpt
This study aimed to investigate in a population of Brazilian patients with multiple sclerosis (MS) single-nucleotide polymorphisms (SNP) in the promoter region of IL4 (*33C-T) and receptor IL4R (*Q551R A-G) genes proposed to interfere with disease progression. No significant differences were observed in either of the SNPs investigated between healthy controls (n=135) and MS patients (n=129). However, the IL4+33...
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