Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pleiotropic effects of ATP.Mg2+ binding in the catalytic cycle of ubiquitin-activating enzyme.

The Journal of biological chemistry - 26 May 2006

Tokgöz Zeynep, Bohnsack Richard N, Haas Arthur L

Abstract excerpt

Conjugation of ubiquitin and other Class 1 ubiquitin-like polypeptides to specific protein targets serves diverse regulatory functions in eukaryotes. The obligatory first step of conjugation requires ATP-coupled activation of the ubiquitin-like protein by members of a superfamily of evolutionarily related enzymes. Kinetic and equilibrium studies of the human ubiquitin-activating enzyme (HsUba1a) reveal that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphate
Share to Aspartic Acid
Share to Catalysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Catalytic Domain

Share to Magnesium

Share to Point Mutation

Share to Ubiquitin

Share to Ubiquitin-Activating Enzymes

Source

Identifiers

PMID: 16595681
DOI: 10.1074/jbc.M513562200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pleiotropic effects of ATP.Mg2+ binding in the catalytic cycle of ubiquitin-activating enzyme.PMID 16595681Read ↗

Role of the Zn(2+) motif of E1 in SUMO adenylation.Semantic proximity Read ↗

Mechanistic insight into the allosteric activation of a ubiquitin-conjugating enzyme by RING-type ubiquitin ligases.Semantic proximity Read ↗

Nutrient copper signaling promotes protein turnover by allosteric activation of ubiquitin E2D conjugasesSemantic proximity Read ↗

The distinct functional properties of the nucleotide-binding domain of ATP7B, the human copper-transporting ATPase: analysis of the Wilson disease mutations E1064A, H1069Q, R1151H, and C1104F.Semantic proximity Read ↗

The SNF1 Kinase Ubiquitin-associated Domain Restrains Its Activation, Activity, and the Yeast Life Span.Semantic proximity Read ↗

The Uba4 domain interplay is mediated via a thioester that is critical for tRNA thiolation through Urm1 thiocarboxylation.Semantic proximity Read ↗

Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8.Semantic proximity Read ↗

Evolutionary relationships and structural mechanisms of AAA+ proteins.Semantic proximity Read ↗

Molecular basis for thiocarboxylation and release of Urm1 by its E1-activating enzyme Uba4.Semantic proximity Read ↗

Engineered interfaces of an AAA+ ATPase reveal a new nucleotide-dependent coordination mechanism.Semantic proximity Read ↗

Architecture of the human G-protein-methylmalonyl-CoA mutase nanoassembly for B <sub>12</sub> delivery and repairSemantic proximity Read ↗

Dissecting the Specificity of Adenosyl Sulfamate Inhibitors Targeting the Ubiquitin-Activating Enzyme.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.