Article
Letter. In vitro phenotypic susceptibility to nucleoside reverse transcriptase inhibitors of HIV-2 isolates with the Q151M mutation in the reverse transcriptase gene.
Antiviral therapy - 1 Jan 2005
Damond Florence, Collin Gilles, Matheron Sophie, Peytavin Gilles, Campa Pauline, Delarue Séverine, Taieb Audrey, Bénard Antoine, Chêne Geneviève, Brun-Vézinet Françoise, Descamps Diane
Abstract excerpt
In HIV-2 infection, many studies have reported a high frequency of selection of the Q151M mutation, but its impact on phenotypic susceptibility of HIV-2 isolates remains unclear. Four HIV-2 infected patients from the French ANRS HIV-2 cohort, with evidence of Q151M mutation in both plasma and available peripheral blood mononuclear cells (PBMCs) co-cultivated supernatants, were selected. In vitro phenotypic...
Topics
- Drug Resistance, Multiple, Viral
- HIV Infections
- HIV-2
- Humans
- Mutation
- Phenotype
- RNA-Directed DNA Polymerase
- Reverse Transcriptase Inhibitors