Mutations at 65 and 70 within the context of a Q151M cluster in human immunodeficiency virus type 1 reverse transcriptase impact the susceptibility to the different nucleoside reverse transcriptase inhibitors in distinct ways.

Abstract excerpt

We report a multinucleoside resistant (MNR) HIV-1 strain that was susceptible towards tenofovir but acquired phenotypic resistance towards tenofovir during in vitro selective pressure both in the presence and in the absence of tenofovir. The original isolate carried the MNR mutations S68G, V75I, F77L, F116Y and Q151M, the lamivudine mutation M184V, the NNRTI mutation K103N and the yet unreported K70S. After in...

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