Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A single-molecule PCR approach to the measurement of induced expanded simple tandem repeat instability in vitro.

Mutation research - 22 Feb 2006

Polyzos Aris, Parfett Craig, Healy Caroline, Douglas George, Yauk Carole

Abstract excerpt

Sensitive and precise models are needed to identify potential genotoxicity at environmentally relevant doses of mutagens. The size length alterations in expanded simple tandem repeat (ESTR) loci have been used as a biomarker of genetic instability caused by a variety of agents in the mouse germline. The mechanisms operating in both spontaneous and induced instability are poorly understood. We have developed a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line
Share to Gene Frequency
Share to Genomic Instability

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to In Vitro Techniques

Share to Mice, Inbred C3H

Share to Minisatellite Repeats

Share to Polymerase Chain Reaction

Source

Identifiers

PMID: 16310811
DOI: 10.1016/j.mrfmmm.2005.08.010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A single-molecule PCR approach to the measurement of induced expanded simple tandem repeat instability in vitro.PMID 16310811Read ↗

A novel single molecule analysis of spontaneous and radiation-induced mutation at a mouse tandem repeat locus.Semantic proximity Read ↗

Tandem repeat mutation, global DNA methylation, and regulation of DNA methyltransferases in cultured mouse embryonic fibroblast cells chronically exposed to chemicals with different modes of action.Semantic proximity Read ↗

Age-related accumulation of mutations supports a replication-dependent mechanism of spontaneous mutation at tandem repeat DNA Loci in mice.Semantic proximity Read ↗

Exposure to anticancer drugs can result in transgenerational genomic instability in miceSemantic proximity Read ↗

Detection of radiation and cyclophosphamide-induced mutations in individual mouse sperm at a human expanded trinucleotide repeat locus transgene.Semantic proximity Read ↗

Duplex sequencing identifies unique characteristics of ENU-induced mutations in male mouse germ cells†.Semantic proximity Read ↗

Characterization of unstable microsatellites in mice: no evidence for germline mutation induction following gamma-radiation exposure.Semantic proximity Read ↗

Radiation-Induced Mutation at Tandem Repeat DNA Loci in the Mouse Germline: Spectra and Doubling DosesSemantic proximity Read ↗

The effects of methyl-donor deficiency on mutation induction and transgenerational instability in mice.Semantic proximity Read ↗

No evidence for transgenerational genomic instability in the F1 or F2 descendants of Muta™Mouse males exposed to N-ethyl-N-nitrosourea.Semantic proximity Read ↗

Age and insertion site dependence of repeat number instability of a human DM1 transgene in individual mouse sperm.Semantic proximity Read ↗

The effects of in utero irradiation on mutation induction and transgenerational instability in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.