Article
Tandem repeat mutation, global DNA methylation, and regulation of DNA methyltransferases in cultured mouse embryonic fibroblast cells chronically exposed to chemicals with different modes of action.
Environmental and molecular mutagenesis - 1 Jan 2008
Yauk Carole L, Polyzos Aris, Rowan-Carroll Andrea, Kortubash Igor, Williams Andrew, Kovalchuk Olga
Abstract excerpt
Mutations at expanded simple tandem repeat (ESTR) DNA sequences provide a useful tool for screening germline mutation. However, the mechanisms resulting in induced mutations are unknown and provide an impediment to the utility of the method. Induced ESTR mutations arise through a nontargeted mech...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.