Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Detection of radiation and cyclophosphamide-induced mutations in individual mouse sperm at a human expanded trinucleotide repeat locus transgene.

Mutation research - 26 Apr 2002

Zhang Yun, Monckton Darren G, Siciliano Michael J, Connor Thomas H, Meistrich Marvin L

Abstract excerpt

A method to measure the germline mutations induced by cancer treatment in humans is needed. To establish such a method we used a transgenic mouse model consisting of a human DNA repeat locus that has a high spontaneous mutation frequency as a biomarker. Alterations in repeat number were measured in individual sperm from mice hemizygous for an expanded (CTG)(162) human myotonic dystrophy type 1 (DM1)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents, Alkylating
Share to Blotting, Southern

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclophosphamide

Share to Myotonic Dystrophy

Share to Myotonin-Protein Kinase

Share to Spermatozoa

Share to Trinucleotide Repeat Expansion

Share to Whole-Body Irradiation

Source

Identifiers

PMID: 11943618
DOI: 10.1016/s1383-5718(02)00035-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Detection of radiation and cyclophosphamide-induced mutations in individual mouse sperm at a human expanded trinucleotide repeat locus transgene.PMID 11943618Read ↗

Age and insertion site dependence of repeat number instability of a human DM1 transgene in individual mouse sperm.Semantic proximity Read ↗

A novel single molecule analysis of spontaneous and radiation-induced mutation at a mouse tandem repeat locus.Semantic proximity Read ↗

Assessing Radiation-Associated Mutational Risk to the Germline: Repetitive DNA Sequences as Mutational Targets and BiomarkersSemantic proximity Read ↗

Characterization of unstable microsatellites in mice: no evidence for germline mutation induction following gamma-radiation exposure.Semantic proximity Read ↗

Duplex sequencing identifies unique characteristics of ENU-induced mutations in male mouse germ cells†.Semantic proximity Read ↗

A single-molecule PCR approach to the measurement of induced expanded simple tandem repeat instability in vitro.Semantic proximity Read ↗

Exposure to anticancer drugs can result in transgenerational genomic instability in miceSemantic proximity Read ↗

Characteristics of induced mutations in offspring derived from irradiated mouse spermatogonia and mature oocytes.Semantic proximity Read ↗

Minisatellite mutation frequency in human sperm following radiotherapy.Semantic proximity Read ↗

Tandem repeat mutation, global DNA methylation, and regulation of DNA methyltransferases in cultured mouse embryonic fibroblast cells chronically exposed to chemicals with different modes of action.Semantic proximity Read ↗

Radiation-induced germline mutations detected by a direct comparison of parents and first-generation offspring DNA sequences containing SNPs.Semantic proximity Read ↗

Pms2 is a genetic enhancer of trinucleotide CAG.CTG repeat somatic mosaicism: implications for the mechanism of triplet repeat expansion.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.