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Article

Age and insertion site dependence of repeat number instability of a human DM1 transgene in individual mouse sperm.

Human molecular genetics - 1 Apr 2002

Zhang Yun, Monckton Darren G, Siciliano Michael J, Connor Thomas H, Meistrich Marvin L

Abstract excerpt

Precise measurement of germline repeat number mutations is important for understanding the molecular etiology of expanded trinucleotide repeat diseases. We used single genome-equivalent PCR of sperm DNA to measure the mutation frequencies in two lines of Dmt transgenic mice containing an expanded CTG.CAG tract on an identical genetic background. Single genome-equivalent PCR indicated that apparent mutational...

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Source

Identifiers

PMID: 11929851
DOI: 10.1093/hmg/11.7.791

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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