Article
Individual mice can be distinguished by the period of their islet calcium oscillations: is there an intrinsic islet period that is imprinted in vivo?
Diabetes - 1 Dec 2005
Nunemaker Craig S, Zhang Min, Wasserman David H, McGuinness Owen P, Powers Alvin C, Bertram Richard, Sherman Arthur, Satin Leslie S
Abstract excerpt
Pulsatile insulin secretion in vivo is believed to be derived, in part, from the intrinsic glucose-dependent intracellular calcium concentration ([Ca2+]i) pulsatility of individual islets. In isolation, islets display fast, slow, or mixtures of fast and slow [Ca2+]i oscillations. We show that the period of islet [Ca2+]i oscillations is unique to each mouse, with the islets from an individual mouse demonstrating...
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