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Mouse models and the genetics of diabetes: is there evidence for genetic overlap between type 1 and type 2 diabetes?

Diabetes - 1 Dec 2005

Leiter Edward H, Lee Chul-Ho

Abstract excerpt

In humans, both type 1 and type 2 diabetes exemplify genetically heterogeneous complex diseases in which epigenetic factors contribute to underlying genetic susceptibility. Extended human pedigrees often show inheritance of both diabetes types. A common pathophysiological denominator in both disease forms is pancreatic beta-cell exposure to proinflammatory cytokines. Hence, it is intuitive that systemically...

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PMID: 16306333
DOI: 10.2337/diabetes.54.suppl_2.s151

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Source receipt: pubmed, retrieved 7 Sept 2026.

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