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Article

Expression of ST3GAL4 leads to SLe(x) expression and induces c-Met activation and an invasive phenotype in gastric carcinoma cells.

PloS one - 1 Jan 2013

Gomes Catarina, Osório Hugo, Pinto Marta Teixeira, Campos Diana, Oliveira Maria José, Reis Celso A

Abstract excerpt

Sialyl-Lewis X (SLe(x)) is a sialylated glycan antigen expressed on the cell surface during malignant cell transformation and is associated with cancer progression and poor prognosis. The increased expression of sialylated glycans is associated with alterations in the expression of sialyltransferases (STs). In this study we determined the capacity of ST3GAL3 and ST3GAL4 sialyltransferases to synthesize the SLe(x)...

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Source

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Identifiers

PMID: 23799130
DOI: 10.1371/journal.pone.0066737
PMCID: PMC3682978

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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