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Article

A comparative study of uracil-DNA glycosylases from human and herpes simplex virus type 1.

The Journal of biological chemistry - 24 Feb 2006

Krusong Kuakarun, Carpenter Elisabeth P, Bellamy Stuart R W, Savva Renos, Baldwin Geoff S

Abstract excerpt

Uracil-DNA glycosylase (UNG) is the key enzyme responsible for initiation of base excision repair. We have used both kinetic and binding assays for comparative analysis of UNG enzymes from humans and herpes simplex virus type 1 (HSV-1). Steady-state fluorescence assays showed that hUNG has a much higher specificity constant (k(cat)/K(m)) compared with the viral enzyme due to a lower K(m). The binding of UNG to...

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Identifiers

PMID: 16306042
DOI: 10.1074/jbc.M509137200

Genes

UNG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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