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Article

Characterization of human cytomegalovirus uracil DNA glycosylase (UL114) and its interaction with polymerase processivity factor (UL44).

Journal of molecular biology - 29 Aug 2008

Ranneberg-Nilsen Toril, Dale Hege Avsnes, Luna Luisa, Slettebakk Ragnhild, Sundheim Ottar, Rollag Halvor, Bjørås Magnar

Abstract excerpt

Here, we report the molecular characterization of the human cytomegalovirus uracil DNA glycosylase (UNG) UL114. Purified UL114 was shown to be a DNA glycosylase, which removes uracil from double-stranded and single-stranded DNA. However, kinetic analysis has shown that viral UNG removed uracil more slowly compared with the core form of human UNG (Delta84hUNG), which has a catalytic efficiency (k(cat)/K(M)) 350-...

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Identifiers

PMID: 18599070
DOI: 10.1016/j.jmb.2008.05.028

Genes

UNG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Characterization of human cytomegalovirus uracil DNA glycosylase (UL114) and its interaction with polymerase processivity factor (UL44).PMID 18599070Read ↗

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