Article
Polymorphisms in genes encoding acetylsalicylic acid metabolizing enzymes are unrelated to upper gastrointestinal health in cardiovascular patients on acetylsalicylic acid.
British journal of clinical pharmacology - 1 Dec 2005
van Oijen Martijn G H, Huybers Sylvie, Peters Wilbert H M, Drenth Joost P H, Laheij Robert J F, Verheugt Freek W A, Jansen Jan B M J
Abstract excerpt
BACKGROUND: As acetylsalicylic acid is metabolized by UDP-glucuronosyltransferase 1A6 (UGT1A6) and cytochrome P450 2C9 (CYP2C9), interindividual differences in activity of these enzymes may modulate the effects and side-effects of acetylsalicylic acid. The objective of this study was to assess whether polymorphisms in UGT1A6 and CYP2C9 genes are related to the prevalence of upper gastrointestinal symptoms in...
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