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Article

UGT1A6 polymorphism and salicylic acid glucuronidation following aspirin.

Pharmacogenetics and genomics - 1 Aug 2007

Chen Yu, Kuehl Gwendolyn E, Bigler Jeannette, Rimorin Christine F, Schwarz Yvonne, Shen Danny D, Lampe Johanna W

Abstract excerpt

OBJECTIVES: In vivo, aspirin (acetylsalicylic acid) is rapidly deacetylated to form salicylic acid, which then undergoes primary or secondary glucuronidation catalyzed by UDP-glucuronosyltransferases (UGTs). The variant UGT1A6*2 (T181A, R184S) is associated with altered enzyme function. Our objective was to compare salicylic acid glucuronidation in individuals with different UGT1A6 genotypes. METHODS: Following...

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Identifiers

PMID: 17622933
DOI: 10.1097/01.fpc.0000236339.79916.07

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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