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Article

NAT1 genotypes do not predict response to mesalamine in patients with ulcerative colitis.

Zeitschrift fur Gastroenterologie - 1 Mar 2008

Hausmann M, Paul G, Menzel K, Brunner-Ploss R, Falk W, Schölmerich J, Herfarth H, Rogler G

Abstract excerpt

BACKGROUND: 5- Aminosalicylic acid (5-ASA) is metabolised in colonic mucosa by N-acetyltransferase 1 (NAT1). Common genetic polymorphisms in this enzyme result in rapid or slow acetylation. 5-ASA treatment causes side effects in up to 10 % of patients with ulcerative colitis (UC). We therefore de...

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Share to Anti-Inflammatory Agents, Non-Steroidal
Share to Arylamine N-Acetyltransferase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18322880
DOI: 10.1055/s-2007-963673

Genes

NAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18322880-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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