Article
Genetic polymorphisms in UDP-glucuronosyltransferase 1A6 are not associated with NSAIDs-related peptic ulcer haemorrhage.
Drug metabolism letters - 1 Aug 2009
van Oijen Martijn G H, Koetsier Marjolein I A, Laheij Robert J F, Roelofs Hennie M J, te Morsche René H M, Peters Wilbert H M, Verheugt Freek W A, Jansen Jan B M J, Drenth Joost P H
Abstract excerpt
UDP-glucuronosyltransferase 1A6 (UGT1A6) is involved in metabolizing non-steroidal anti-inflammatory drugs (NSAIDs). Genotype variation in UGT1A6 may influence the metabolism of NSAIDs and we studied whether this might modulate the gastrointestinal toxicity of NSAIDs. UGT1A6 genotypes of 114 pati...
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