Article
Advances in understanding the biology and genetics of acute myelocytic leukemia.
Clinical laboratory science : journal of the American Society for Medical Technology - 1 Jan 2005
McKenzie Shirlyn B
Abstract excerpt
Acute myelocytic leukemia (AML) is a malignant neoplasm of hematopoietic cells characterized by an abnormal proliferation of myeloid precursor cells, decreased rate of self-destruction and an arrest in cellular differentiation. The leukemic cells have an abnormal survival advantage. Thus, the bone marrow and peripheral blood are characterized by leukocytosis with a predominance of immature cells, primarily...
Topics
- Cytogenetics
- Humans
- Immunophenotyping
- Leukemia, Myeloid, Acute
- Leukemia, Promyelocytic, Acute
- Molecular Biology
- Mutation
- Neoplasm Proteins
- Oncogene Proteins, Fusion
- Remission Induction
- Translocation, Genetic