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Article

The DHHC protein Pfa3 affects vacuole-associated palmitoylation of the fusion factor Vac8.

Proceedings of the National Academy of Sciences of the United States of America - 29 Nov 2005

Hou Haitong, Subramanian Kanagaraj, LaGrassa Tracy J, Markgraf Daniel, Dietrich Lars E P, Urban Jörg, Decker Nadine, Ungermann Christian

Abstract excerpt

Vacuole biogenesis depends on specific targeting and retention of peripheral membrane proteins. At least three palmitoylated proteins are found exclusively on yeast vacuoles: the fusion factor Vac8, the kinase Yck3, and a novel adaptor protein implicated in microautophagy, Meh1. Here, we analyze the role that putative acyltransferases of the DHHC family play in their localization and function. We find that...

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Identifiers

PMID: 16301533
DOI: 10.1073/pnas.0508885102
PMCID: PMC1297695

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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