Article
Iroquois genes influence proximo-distal morphogenesis during rat lung development.
American journal of physiology. Lung cellular and molecular physiology - 1 Apr 2006
van Tuyl Minke, Liu Jason, Groenman Freek, Ridsdale Ross, Han Robin N N, Venkatesh Vikram, Tibboel Dick, Post Martin
Abstract excerpt
Lung development is a highly regulated process directed by mesenchymal-epithelial interactions, which coordinate the temporal and spatial expression of multiple regulatory factors required for proper lung formation. The Iroquois homeobox (Irx) genes have been implicated in the patterning and specification of several Drosophila and vertebrate organs, including the heart. Herein, we investigated whether the Irx...
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