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Article

The Arctic Alzheimer mutation favors intracellular amyloid-beta production by making amyloid precursor protein less available to alpha-secretase.

Journal of neurochemistry - 1 May 2007

Sahlin Charlotte, Lord Anna, Magnusson Kristina, Englund Hillevi, Almeida Claudia G, Greengard Paul, Nyberg Fred, Gouras Gunnar K, Lannfelt Lars, Nilsson Lars N G

Abstract excerpt

Mutations within the amyloid-beta (Abeta) domain of the amyloid precursor protein (APP) typically generate hemorrhagic strokes and vascular amyloid angiopathy. In contrast, the Arctic mutation (APP E693G) results in Alzheimer's disease. Little is known about the pathologic mechanisms that result from the Arctic mutation, although increased formation of Abeta protofibrils in vitro and intraneuronal Abeta...

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Source

Identifiers

PMID: 17448150
DOI: 10.1111/j.1471-4159.2006.04443.x

Genes

APP

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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