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Article

General and specific alterations in programming of global viral gene expression during infection by VP16 activation-deficient mutants of herpes simplex virus type 1.

Journal of virology - 1 Dec 2002

Yang William C, Devi-Rao G V, Ghazal Peter, Wagner Edward K, Triezenberg Steven J

Abstract excerpt

During productive infection by herpes simplex virus 1 (HSV-1), viral gene expression occurs in a temporally regulated cascade in which transcription of the viral immediate-early (IE) genes is strongly stimulated by the virion protein VP16. We have employed an oligonucleotide microarray to examine the effect of VP16 mutations on the overall pattern of viral gene expression following infection of HeLa cells. This...

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Identifiers

PMID: 12438601
DOI: 10.1128/jvi.76.24.12758-12774.2002
PMCID: PMC136702

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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General and specific alterations in programming of global viral gene expression during infection by VP16 activation-deficient mutants of herpes simplex virus type 1.PMID 12438601Read ↗

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