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Article

Physiogenomic analysis links serum creatine kinase activities during statin therapy to vascular smooth muscle homeostasis.

Pharmacogenomics - 1 Dec 2005

Ruaño Gualberto, Thompson Paul D, Windemuth Andreas, Smith Andrew, Kocherla Mohan, Holford Theodore R, Seip Richard, Wu Alan Hb

Abstract excerpt

Statins are highly effective at reducing coronary disease risk. The main side effects of these medications are a variety of skeletal muscle complaints ranging from mild myalgia to frank rhabdomyolysis. To search for physiologic factors possibly influencing statin muscle toxicity, we screened for genetic associations with serum creatine kinase (CK) levels in 102 patients receiving statin therapy for...

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Source

Identifiers

PMID: 16296949
DOI: 10.2217/14622416.6.8.865

Genes

AGTR1
NOS3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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