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Article

Dominant negative N-cadherin inhibits osteoclast differentiation by interfering with beta-catenin regulation of RANKL, independent of cell-cell adhesion.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Dec 2005

Shin Chan Soo, Her Sun-Ju, Kim Jeong-Ah, Kim Do Hee, Kim Sang Wan, Kim Seong Yeon, Kim Hyo-Soo, Park Ki Ho, Kim Jung Gu, Kitazawa Riko, Cheng Su-Li, Civitelli Roberto

Abstract excerpt

UNLABELLED: We studied the effects of dominant negative N-cadherin (NCadDeltaC) expression in ST2 cells on their ability to support osteoclastogenesis. Expression of NCadDeltaC in ST2 cells did not decrease cell-to-cell adhesion but significantly reduced osteoclast formation when co-cultured with BMMs. NCadDeltaC inhibited beta-catenin/TCF signaling, resulting in decreased RANKL expression, which could contribute...

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PMID: 16294273
DOI: 10.1359/JBMR.050809

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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