Article
Inhibition of cell adhesion by a cadherin-11 antibody thwarts bone metastasis.
Molecular cancer research : MCR - 1 Nov 2013
Lee Yu-Chen, Bilen Mehmet Asim, Yu Guoyu, Lin Song-Chang, Huang Chih-Fen, Ortiz Angelica, Cho Hyojin, Song Jian H, Satcher Robert L, Kuang Jian, Gallick Gary E, Yu-Lee Li-Yuan, Huang Wilber, Lin Sue-Hwa
Abstract excerpt
UNLABELLED: Cadherin-11 (CDH11) is a member of the cadherin superfamily mainly expressed in osteoblasts but not in epithelial cells. However, prostate cancer cells with a propensity for bone metastasis express high levels of cadherin-11 and reduced levels of E-cadherin. Downregulation of cadherin-11 inhibits interaction of prostate cancer cells with osteoblasts in vitro and homing of prostate cancer cells to bone...
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