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Article

Effect of a triphasic oral contraceptive on drug-metabolizing enzyme activity as measured by the validated Cooperstown 5+1 cocktail.

Journal of clinical pharmacology - 1 Dec 2005

Shelepova Tatiana, Nafziger Anne N, Victory Jennifer, Kashuba Angela D M, Rowland Elizabeth, Zhang Yanhua, Sellers Edward, Kearns Gregory, Leeder J Steven, Gaedigk Andrea, Bertino Joseph S

Abstract excerpt

The effects of a common oral contraceptive preparation on the activity of 7 drug-metabolizing enzymes were investigated using the validated Cooperstown 5+1 Cocktail. In a randomized crossover fashion, 10 premenopausal women received caffeine, dextromethorphan, omeprazole, intravenous midazolam, and warfarin + vitamin K with and without a triphasic oral contraceptive (ethinyl estradiol 35 microg) and varying doses...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16291717
DOI: 10.1177/0091270005280851

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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