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Article

Partial Decay of Thiamine Signal Transduction Pathway Alters Growth Properties of Candida glabrata.

PloS one - 1 Jan 2016

Iosue Christine L, Attanasio Nicholas, Shaik Noor F, Neal Erin M, Leone Sarah G, Cali Brian J, Peel Michael T, Grannas Amanda M, Wykoff Dennis D

Abstract excerpt

The phosphorylated form of thiamine (Vitamin B1), thiamine pyrophosphate (TPP) is essential for the metabolism of amino acids and carbohydrates in all organisms. Plants and microorganisms, such as yeast, synthesize thiamine de novo whereas animals do not. The thiamine signal transduction (THI) pathway in Saccharomyces cerevisiae is well characterized. The ~10 genes required for thiamine biosynthesis and uptake...

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Identifiers

PMID: 27015653
DOI: 10.1371/journal.pone.0152042
PMCID: PMC4807840

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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