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Article

Translational options for the pir gene of plasmid R6K: multiple forms of the replication initiator protein pi.

Gene - 1 Jul 1992

York D, Ivanov V, Gan J, Filutowicz M

Abstract excerpt

The autogenously controlled pir gene of plasmid R6K was believed to encode a single polypeptide that plays multiple roles in the plasmid's biology. We have isolated an opal (op) mutant at the 18th codon of the pir coding frame which does not totally abolish translation of pir mRNA. In extracts of cells containing this mutation two translational products (35 kDa and 30.2 kDa) have been detected. We propose that...

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Identifiers

PMID: 1628846
DOI: 10.1016/0378-1119(92)90622-v

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Translational options for the pir gene of plasmid R6K: multiple forms of the replication initiator protein pi.PMID 1628846Read ↗

Autoregulation-deficient mutant of the plasmid R6K-encoded pi protein distinguishes between palindromic and nonpalindromic binding sites.Semantic proximity Read ↗

Identification of a novel promoter in the replication control region of plasmid R6K.Semantic proximity Read ↗

Structure-based functional analysis of the replication protein of plasmid R6K: key amino acids at the pi/DNA interface.Semantic proximity Read ↗

Translation initiation of the replication initiator repB gene of promiscuous plasmid pMV158 is led by an extended non-SD sequence.Semantic proximity Read ↗

N-terminal truncated forms of the bifunctional pi initiation protein express negative activity on plasmid R6K replication.Semantic proximity Read ↗

Location of a P1 plasmid replication inhibitor determinant within the initiator gene.Semantic proximity Read ↗

Biochemical investigations of control of replication initiation of plasmid R6K.Semantic proximity Read ↗

Replication of the R6K gamma origin in vitro: dependence on wt pi and hyperactive piS87N protein variant.Semantic proximity Read ↗

The DnaK-DnaJ-GrpE chaperone system activates inert wild type pi initiator protein of R6K into a form active in replication initiation.Semantic proximity Read ↗

Cooperative binding of initiator protein to replication origin conferred by single amino acid substitution.Semantic proximity Read ↗

Identification of a potential membrane-targeting region of the replication initiator protein (TrfA) of broad-host-range plasmid RK2.Semantic proximity Read ↗

A specific region in the N terminus of a replication initiation protein of plasmid RK2 is required for recruitment of Pseudomonas aeruginosa DnaB helicase to the plasmid origin.Semantic proximity Read ↗

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