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Article

Human papillomavirus mediated inhibition of DNA damage sensing and repair drives skin carcinogenesis

28 Oct 2015

Abstract excerpt

BACKGROUND: The failure to mount an effective DNA damage response to repair UV induced cyclobutane pyrimidine dimers (CPDs) results in an increased propensity to develop cutaneous squamous cell carcinoma (cSCC). High-risk patient groups, such as organ transplant recipients (OTRs) frequently exhibit field cancerization at UV exposed body sites from which multiple human papillomavirus (HPV)-associated cSCCs develop...

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PMID: 26511842
DOI: 10.1186/s12943-015-0453-7

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