Article
Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk.
Nature genetics - 1 Oct 2002
Xu Jianfeng, Zheng S Lilly, Komiya Akira, Mychaleckyj Josyf C, Isaacs Sarah D, Hu Jennifer J, Sterling David, Lange Ethan M, Hawkins Gregory A, Turner Aubrey, Ewing Charles M, Faith Dennis A, Johnson Jill R, Suzuki Hiroyoshi, Bujnovszky Piroska, Wiley Kathleen E, DeMarzo Angelo M, Bova G Steven, Chang Baoli, Hall M Craig, McCullough David L, Partin Alan W, Kassabian Vahan S, Carpten John D, Bailey-Wilson Joan E, Trent Jeffrey M, Ohar Jill, Bleecker Eugene R, Walsh Patrick C, Isaacs William B, Meyers Deborah A
Abstract excerpt
Deletions on human chromosome 8p22-23 in prostate cancer cells and linkage studies in families affected with hereditary prostate cancer (HPC) have implicated this region in the development of prostate cancer. The macrophage scavenger receptor 1 gene (MSR1, also known as SR-A) is located at 8p22 and functions in several processes proposed to be relevant to prostate carcinogenesis. Here we report the results of...
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