Article
BRCA1 mutations and prostate cancer in Poland.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) - 1 Feb 2008
Cybulski Cezary, Górski Bohdan, Gronwald Jacek, Huzarski Tomasz, Byrski Tomasz, Debniak Tadeusz, Jakubowska Anna, Wokołorczyk Dominika, Gliniewicz Bartłomiej, Sikorski Andrzej, Stawicka Małgorzata, Godlewski Dariusz, Kwias Zbigniew, Antczak Andrzej, Krajka Kazimierz, Lauer Wojciech, Sosnowski Marek, Sikorska-Radek Paulina, Bar Krzysztof, Klijer Robert, Romuald Zdrojowy, Małkiewicz Bartosz, Borkowski Andrzej, Borkowski Tomasz, Szwiec Marek, Posmyk Michal, Narod Steven A, Lubiński Jan
Abstract excerpt
Evidence to date that BRCA1 mutation carriers are at an increased risk of prostate cancer is mixed - both positive and negative studies have been published. To establish whether or not inherited variation in BRCA1 influences prostate cancer risk we genotyped 1793 men with prostate cancer in Poland and 4570 controls for three founder mutations (C61G, 4153delA and 5382insC). A BRCA1 mutation was present in 0.45% of...
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