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Combinatorial morphogenetic and mechanical cues to mimic bone development for defect repair

2 Aug 2019

Abstract excerpt

Endochondral ossification during long bone development and natural fracture healing initiates by mesenchymal cell condensation, directed by local morphogen signals and mechanical cues. Here, we aimed to mimic development for regeneration of large bone defects. We hypothesized that engineered human mesenchymal condensations presenting transforming growth factor-β1 (TGF-β1) and/or bone morphogenetic protein-2...

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PMID: 31489377
DOI: 10.1126/sciadv.aax2476

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