Article

Combinatorial morphogenetic and mechanical cues to mimic bone development for defect repair

2019-02-26

Abstract excerpt

Endochondral ossification during long bone development and natural fracture healing initiates by mesenchymal cell condensation and is directed by local morphogen signals and mechanical cues. Here, we aimed to mimic these developmental conditions for regeneration of large bone defects. We hypothesized that engineered human mesenchymal stem cell (hMSC) condensations with in situ presentation of transforming growth...

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Literature Corpus work: 1f779778-e164-5684-996d-4e3532ae25ba
DOI: 10.1101/561837

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