Enhancement of Bone Healing Based on <i>Ex Vivo</i> Gene Therapy Using Human Muscle-Derived Cells Expressing Bone Morphogenetic Protein 2

Abstract excerpt

Molecular biological advances have allowed the use of gene therapy in a clinical setting. In addition, numerous reports have indicated the existence of inducible osteoprogenitor cells in skeletal muscle. Because of this, we hypothesized that skeletal muscle cells might be ideal vehicles for delivery of bone-inductive factors. Using ex vivo gene transfer methods, we genetically engineered freshly isolated human...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Mesenchymal stem cell research
• Share to Muscle Physiology and Disorders
• Share to Tissue Engineering and Regenerative Medicine